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San Diego Digestive Diseases Research Center SDDRC

Upcoming Center Seminars


October 2026

Date:
Monday, October 26, 2026, 12:00 – 1:00 pm, Pacific Time, Hybrid Meeting

Location: Leichtag - 107 (Lecture Room)

Online: Zoom Meeting
Password: 112376

Speaker: 
Takeshi Saito, MD, PhD, AGAF, FAASLD
Veronica P. Budnick Chair in Liver Disease
Professor of Medicine, Division of Gastrointestinal and Liver Diseases
Professor of Immunology & Immune Therapeutics, and Pathology
Keck School of Medicine, University of Southern California
Los Angeles, CA

Title: Hepatocyte-Intrinsic Humoral Factors Self-Assemble into an Autocrine Cell Identity Determining Niche 

Speaker’s Research Interests: Cell fate determination and identity preservation depend on interactions with tissue-specific microenvironmental niches. Loss of these microenvironmental cues is considered a major driver of the rapid decline in authentic cellular characteristics during in vitro culture. However, primary human hepatocytes exhibit a robust capacity to preserve identity marker gene expression, authentic morphology, and specialized functions. This observation challenges the prevailing view that maintenance of hepatocyte identity requires a tissue-specific niche provided primarily by hepatic non-parenchymal cells. In this seminar, Dr. Saito will address a fundamental question in liver cell biology: how do mature hepatocytes preserve their highly specialized identity within a mechanically and molecularly dynamic tissue environment? To address this question, his laboratory leverages its extensive expertise in primary human hepatocyte culture and humanized liver chimeric mouse models. Beyond this work, his laboratory applies these human-based experimental platforms to mechanistic studies of viral hepatitis, cholestatic disease, and metabolic liver disease to develop physiologically relevant and predictive disease models and identify novel therapeutic targets, with the ultimate goal of mitigating the burden of liver disease.


November 2026

Date:
Monday, November 30, 2026, 12:00 – 1:00 pm, Pacific Time, Hybrid Meeting

Location: Leichtag - 107 (Lecture Room)

Speaker: 
Lee A. Denson, MD
Professor of Pediatrics
Director, Schubert-Martin IBD Center
Director, Digestive Health Center
Research Director, Gastroenterology, Hepatology, and Nutrition
Cincinnati Children’s Hospital Medical Center
Cincinnati, OH

Title: TBD

Speaker’s Research Interests: TBD


December 2026

Date:
Monday, December 14, 2026, 12:00 – 1:00 pm, Pacific Time, Hybrid Meeting

Location: Leichtag - 107 (Lecture Room)

Speaker: 
Stephen A. Duncan, DPhil
Professor and Chair
Department: Regenerative Medicine & Cell Biology
Programs: Cell Injury, End Organ Disease
Cell Models Core
Medical University of South Carolina (MUSC)
Charleston, SC

Title: TBD

Speaker’s Research Interests: TBD


December 2026

Date:
Wednesday, December 16, 2026, 3:30 – 4:30 pm, Pacific Time, Hybrid Meeting

Location: MET Lower Auditorium

Speaker: 
Hans Clevers, PhD
Hubrecht Institute
Netherlands

Title: TBD

Speaker’s Research Interests: TBD


January 2027

Date:
Monday, January 25, 2027, 12:00 – 1:00 pm, Pacific Time, Hybrid Meeting

Location: Leichtag - 107 (Lecture Room)

Speaker: 
Scott T. Magness, Ph.D.
Associate Professor
Joint Dept. of Biomedical Engineering, NCSU/UNC-CH
Dept. of Cell & Molecular Physiology
Director, CGIBD Advanced Analytics Core
School of Medicine
The University of North Carolina at Chapel Hill

Title: TBD

Speaker’s Research Interests: TBD


March 2027

Date:
Monday, March 22, 2027, 12:00 – 1:00 pm, Pacific Time, Hybrid Meeting

Location: TBD

Speaker: 
Anna Suk-Fong Lok, MD
Dame Sheila Sherlock, Distinguished University Professor of Hepatology and Internal Medicine
Alice Lohrman Andrews Research Professor of Hepatology
Assistant Dean for Clinical Research
University of Michigan Medical School
Ann Arbor, MI

Title: TBD

Speaker’s Research Interests: TBD



March 2027

Date:
Wednesday, March 24, 2027, 7:30 – 8:30 am, Pacific Time, Hybrid Meeting

Location: TBD

Speaker: 
Reza Shaker, MD
Professor
Department of Medicine
Division of Gastroenterology and Hepatology
Medical College of Wisconsin
Milwaukee, WI

Title: TBD

Speaker’s Research Interests: TBD


April 2027

Date:
Wednesday, April 28, 2027, 7:30 – 8:30 am, Pacific Time, Hybrid Meeting

Location: TBD

Speaker: 
Suthat Liangpunsakul, MD, MPH
Professor of Medicine
Professor of Biochemistry, Molecular Biology & Pharmacology
Associate Chief of Staff for Research, Roudebush Veterans Administration Medical Center
Indiana University School of Medicine
Indianapolis, IN

Title: TBD

Speaker’s Research Interests: TBD


May 2027

Date:
Monday, May 24, 2027, 12:00 – 1:00 pm, Pacific Time, Hybrid Meeting

Location: Leichtag - 107 (Lecture Room)

Speaker: 
Arielle Klepper, MD, PhD
Assistant Professor, Medicine
Division of Gastroenterology & Hepatology
University of California, San Francisco

Title: TBD

Speaker’s Research Interests: TBD